SRP68

Across TCGA patient cohorts, SRP68 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP68-associated genes across cancer lineages are ER-alpha_pS118, MEK1, and p62 Lck ligand. Each is linked with SRP68 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP68-to-partner and partner-to-SRP68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by SRP68-low versus SRP68-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP68→partner) and Y-score (partner→SRP68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ER-alpha_pS118 →	+0.175	+2.820	.008	.035	3	2
UCEC	MEK1 →	+0.319	+1.906	.030	.016	3	2
UCEC	p62 Lck ligand →	+0.280	+1.906	.032	.016	3	2
UCEC	Di-Ras3 →	-0.130	-1.906	.029	.016	3	2
UCEC	EGFR_pY1068 →	-0.240	-1.906	.017	.016	3	1
UCEC	A-Raf_pS299 →	-0.116	-3.169	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ER-alpha_pS118 by SRP68 expression — BLCA

Explore this box plot interactively →