SRP68

Across TCGA cell cohorts, SRP68 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,276 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRP68-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Positive regulation of hematopoietic stem cell proliferation. Each is linked with SRP68 in more than 13 cancer types. Because this analysis shows association rather than direction, both SRP68-to-partner and partner-to-SRP68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle grouped by SRP68-low versus SRP68-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP68→partner) and Y-score (partner→SRP68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of mitotic cell cycle →	+0.089	+0.755	<.001	<.001	3	14
LARGE_INTESTINE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.120	+0.873	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of hematopoietic stem cell proliferation →	+0.124	+0.501	<.001	<.001	3	13
BONE	Positive regulation of nuclear cell cycle DNA replication →	+0.132	+0.395	<.001	.001	3	13
LARGE_INTESTINE	Regulation of pentose-phosphate shunt →	+0.113	+0.609	<.001	<.001	3	12
PANCREAS	Meiotic cell cycle →	+0.080	+0.656	.003	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,276 associations by consensus.

Positive regulation of mitotic cell cycle by SRP68 expression — KIDNEY

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