SRP54

Across TCGA pan-cancer cohorts, SRP54 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRP54 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRP54 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SRP54 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where SRP54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.972	0.735	<.001	53	view →
UCEC	DFS	Tertile	All	1.000	0.794	.001	22	view →
LUAD	OS	Median	All	0.639	0.862	.006	6	view →
LSCC	DFS	Median	All	0.907	0.464	.009	3	view →
PDAC	DFS	Quartile	II,III,IV	0.815	0.699	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRP54–HNSC (OS)

Open the HNSC breakdown →