SRP54

Across TCGA patient cohorts, SRP54 protein abundance is significantly associated with the RNA expression of many other genes, with 17,572 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SRP54-associated genes across cancer lineages are CRYAB, WTIP, and PTPRG. Each is linked with SRP54 in more than 5 cancer types. Because this analysis shows association rather than direction, both SRP54-to-partner and partner-to-SRP54 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRP54 versus CRYAB in BRCA, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP54→partner) and Y-score (partner→SRP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRYAB →	-1.286	-0.157	<.001	<.001	3	6
LUAD	WTIP →	-0.689	-0.291	.002	<.001	3	6
LSCC	PTPRG →	-0.686	-0.257	<.001	<.001	3	6
CCRCC	DIXDC1 →	-0.607	-0.183	.003	.003	3	6
GBM	BTBD8 →	-1.040	-0.253	<.001	<.001	3	6
LUAD	MYOM1 →	-0.763	-0.159	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,572 associations by consensus.

SRP54 vs CRYAB — BRCA

Explore this scatter interactively →