SRP54

Across TCGA patient cohorts, SRP54 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP54-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with SRP54 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP54-to-partner and partner-to-SRP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SRP54-low versus SRP54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP54→partner) and Y-score (partner→SRP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.349	+3.169	.030	.019	3	1
UCEC	EGFR_pY1068 →	-0.288	-2.459	.011	.019	3	1
UCEC	eIF4E →	+0.231	+3.013	.015	.018	3	1
UCEC	Fibronectin →	-0.301	-3.160	.042	.019	3	1
UCEC	INPP4B →	-0.301	-2.584	.038	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.161	-2.321	.034	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by SRP54 expression — UCEC

Explore this box plot interactively →