SRP54

Across TCGA cell cohorts, SRP54 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,767 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRP54-associated GO terms across cancer lineages are Golgi vesicle transport, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, and Vesicle targeting. Each is linked with SRP54 in more than 14 cancer types. Because this analysis shows association rather than direction, both SRP54-to-partner and partner-to-SRP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle transport grouped by SRP54-low versus SRP54-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP54→partner) and Y-score (partner→SRP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Golgi vesicle transport →	+0.064	+0.838	.002	.002	3	15
BONE	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.146	+0.567	<.001	<.001	3	14
OESOPHAGUS	Vesicle targeting →	+0.078	+0.970	<.001	<.001	3	14
BLOOD_Lymphoma	Golgi organization →	+0.057	+1.004	<.001	<.001	3	13
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.122	+1.121	<.001	<.001	3	12
URINARY_TRACT	Monoubiquitinated protein deubiquitination →	+0.116	+0.490	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,767 associations by consensus.

Golgi vesicle transport by SRP54 expression — OESOPHAGUS

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