SRP54

Across TCGA cell cohorts, SRP54 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SRP54-associated genes across cancer lineages are PSKH2, LCE2C, and CD300H. Each is linked with SRP54 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP54-to-partner and partner-to-SRP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSKH2 grouped by SRP54-low versus SRP54-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP54→partner) and Y-score (partner→SRP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PSKH2 →	+0.021	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.042	+5.662	<.001	.002	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PSKH2 by SRP54 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →