SRP19

Across TCGA pan-cancer cohorts, SRP19 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRP19 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRP19 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRP19 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and LSCC are the cancer types where SRP19 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.943	0.661	.004	25	view →
COAD	DFS	Median	III,IV	1.000	0.897	.044	12	view →
LSCC	DFS	Quartile	III,IV	0.329	0.868	.006	12	view →
LUAD	OS	Quartile	All	0.596	0.954	.011	10	view →
PDAC	DFS	Quartile	II,III,IV	0.979	0.753	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRP19–HNSC (DFS)

Open the HNSC breakdown →