SRP19

Across TCGA patient cohorts, SRP19 mutation is significantly associated with the RNA expression of many other genes, with 1,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP19-associated genes across cancer lineages are MAGI2-AS2, BNIP3P41, and NOL12. Each is linked with SRP19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP19-to-partner and partner-to-SRP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGI2-AS2 grouped by SRP19-low versus SRP19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP19→partner) and Y-score (partner→SRP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAGI2-AS2 →	+0.104	+3.220	<.001	.005	3	2
UCEC	BNIP3P41 →	+0.015	+4.671	<.001	.002	3	2
UCEC	NOL12 →	+0.363	+2.839	.004	.001	3	1
UCEC	IGKV2-40 →	+0.225	+2.664	.002	.002	3	1
UCEC	ZNF280B →	+0.673	+3.917	<.001	<.001	3	1
UCEC	TRBV16 →	+0.232	+2.329	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,593 associations by consensus.

MAGI2-AS2 by SRP19 expression — UCEC

Explore this box plot interactively →