SRP19

Across TCGA patient cohorts, SRP19 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP19-associated genes across cancer lineages are eEF2, ERK2, and Ku80. Each is linked with SRP19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP19-to-partner and partner-to-SRP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SRP19-low versus SRP19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP19→partner) and Y-score (partner→SRP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.433	+3.000	.009	.036	3	1
UCEC	ERK2 →	+0.231	+2.584	.009	.010	3	1
UCEC	Ku80 →	+0.268	+2.598	.014	.006	3	1
UCEC	PCNA →	+0.230	+3.321	.022	.010	3	1
UCEC	VHL →	-1.283	-2.459	<.001	.019	3	1
UCEC	Caspase-8 →	-0.236	-3.295	.043	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eEF2 by SRP19 expression — UCEC

Explore this box plot interactively →