SRP19

Across TCGA cell cohorts, SRP19 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,481 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRP19-associated GO terms across cancer lineages are Positive regulation of rRNA processing, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, and CAAX-box protein maturation. Each is linked with SRP19 in more than 11 cancer types. Because this analysis shows association rather than direction, both SRP19-to-partner and partner-to-SRP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of rRNA processing grouped by SRP19-low versus SRP19-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP19→partner) and Y-score (partner→SRP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of rRNA processing →	+0.134	+0.894	<.001	<.001	3	12
BLOOD_Lymphoma	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.113	+0.759	<.001	<.001	3	12
SOFT_TISSUE	CAAX-box protein maturation →	+0.105	+0.629	<.001	.001	3	11
STOMACH	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.072	+0.820	<.001	.002	3	11
LIVER	Positive regulation of protein localization to centrosome →	+0.095	+0.553	.005	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of heart rate by cardiac conduction →	-0.143	-0.567	.004	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,481 associations by consensus.

Positive regulation of rRNA processing by SRP19 expression — LARGE_INTESTINE

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