SRP14

Across TCGA pan-cancer cohorts, SRP14 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SRP14 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRP14 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRP14 expression acts as an unfavorable survival marker.

HNSC, GBM, and PRAD are the cancer types where SRP14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.130	0.685	.003	24	view →
GBM	OS	Median	All	0.026	0.416	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SRP14–HNSC (DFS)

Open the HNSC breakdown →