SRP14

Across TCGA pan-cancer cohorts, SRP14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRP14 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRP14 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SRP14 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

HNSC, GBM, and LUAD are the cancer types where SRP14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.796	1.000	.018	25	view →
GBM	DFS	Quartile	All	0.459	0.234	.004	9	view →
LUAD	DFS	Quartile	II,III,IV	0.335	0.671	.036	5	view →
PDAC	DFS	Quartile	All	0.547	0.346	.026	4	view →
CCRCC	DFS	Median	III,IV	0.821	1.000	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRP14–HNSC (OS)

Open the HNSC breakdown →