SRP14

Across TCGA patient cohorts, SRP14 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP14-associated genes across cancer lineages are RN7SKP286, SNRPGP17, and RPS29P32. Each is linked with SRP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP14-to-partner and partner-to-SRP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by SRP14-low versus SRP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP14→partner) and Y-score (partner→SRP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP286 →	+0.097	+5.253	<.001	.001	3	2
UCEC	SNRPGP17 →	+0.432	+2.879	<.001	.004	3	1
UCEC	RPS29P32 →	+0.929	+3.277	<.001	.002	3	1
UCEC	MIR4449 →	+1.174	+3.239	<.001	.001	3	1
UCEC	MIR3690 →	+0.436	+2.902	.007	.006	3	1
UCEC	CSNK1A1L →	+0.117	+3.651	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

RN7SKP286 by SRP14 expression — UCEC

Explore this box plot interactively →