SRP14

Across TCGA cell cohorts, SRP14 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,409 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SRP14-associated GO terms across cancer lineages are Transcription elongation by RNA polymerase II, Circadian sleep/wake cycle, and Ubiquitin-dependent protein catabolic process via the N-end rule pathway. Each is linked with SRP14 in more than 9 cancer types. Because this analysis shows association rather than direction, both SRP14-to-partner and partner-to-SRP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription elongation by RNA polymerase II grouped by SRP14-low versus SRP14-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP14→partner) and Y-score (partner→SRP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Transcription elongation by RNA polymerase II →	+0.078	+0.448	<.001	.001	3	10
URINARY_TRACT	Circadian sleep/wake cycle →	+0.158	+0.733	.002	<.001	2	10
LIVER	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.093	+0.751	<.001	.004	3	9
BLOOD_Lymphoma	Golgi lumen acidification →	+0.082	+0.600	<.001	<.001	3	8
URINARY_TRACT	Negative regulation of intracellular estrogen receptor signaling pathway →	+0.149	+0.734	<.001	<.001	3	7
BLOOD_Lymphoma	Response to camptothecin →	+0.106	+0.517	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,409 associations by consensus.

Transcription elongation by RNA polymerase II by SRP14 expression — OVARY

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