Across TCGA pan-cancer cohorts, SRMP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SRMP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SRMP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SRMP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRP, and LUSC are the cancer types where SRMP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRMP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.191	<.001	8	view →
KIRP	All	All	+0.122	.002	6	view →
LUSC	All	All	+0.217	<.001	5	view →
THCA	All	All	−0.017	.015	2	view →
KIRC	All	All	+0.033	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SRMP1 RNA expression & survival · all SRMP1 data types