SRM

Across TCGA patient cohorts, SRM mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRM-associated genes across cancer lineages are 14-3-3_beta, Fibronectin, and HER3. Each is linked with SRM in more than 1 cancer types. Because this analysis shows association rather than direction, both SRM-to-partner and partner-to-SRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SRM-low versus SRM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRM→partner) and Y-score (partner→SRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.160	-3.156	.003	.020	3	1
UCEC	Fibronectin →	-0.363	-3.169	.045	.020	3	1
UCEC	HER3 →	-0.334	-3.156	.026	.020	3	1
UCEC	MIG-6 →	-0.197	-3.156	<.001	.020	3	1
UCEC	Myosin-IIa_pS1943 →	+0.237	+3.183	.036	.010	3	1
UCEC	p90 RSK →	+0.240	+3.183	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

14-3-3_beta by SRM expression — UCEC

Explore this box plot interactively →