SRM

Across TCGA cell cohorts, SRM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,318 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SRM-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and DNA-templated transcription termination. Each is linked with SRM in more than 14 cancer types. Because this analysis shows association rather than direction, both SRM-to-partner and partner-to-SRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by SRM-low versus SRM-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRM→partner) and Y-score (partner→SRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	rRNA 5'-end processing →	+0.120	+1.021	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.120	+1.021	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription termination →	+0.110	+1.223	<.001	.001	3	15
BLOOD_Myeloma	rRNA processing →	+0.089	+1.031	.001	.001	3	14
OESOPHAGUS	Maturation of SSU-rRNA →	+0.131	+1.308	.002	.008	3	14
UPPER_AERODIGESTIVE_TRACT	Ribosome biogenesis →	+0.084	+0.979	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,318 associations by consensus.

rRNA 5'-end processing by SRM expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →