Across TCGA patient cohorts, SRL mutation is significantly associated with the RNA expression of many other genes, with 4,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRL-associated genes across cancer lineages are NDUFA6, SNRPD3, and RTCB. Each is linked with SRL in more than 2 cancer types. Because this analysis shows association rather than direction, both SRL-to-partner and partner-to-SRL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRL→partner) and Y-score (partner→SRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.541	+2.332	<.001	<.001	3	3
SKCM	SNRPD3 →	+0.336	+2.189	.004	.001	3	3
UCEC	RTCB →	+0.447	+3.961	.001	<.001	3	3
UCEC	PHF5A →	+0.506	+3.169	<.001	<.001	3	3
UCEC	PGK1 →	+0.853	+3.807	<.001	<.001	3	3
UCEC	GPI →	+0.493	+3.828	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,068 associations by consensus.

Exploration

SRL survival (RNA) · tumor vs normal (RNA) · all SRL data types