Across TCGA patient cohorts, SRL mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRL-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with SRL in more than 1 cancer types. Because this analysis shows association rather than direction, both SRL-to-partner and partner-to-SRL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRL→partner) and Y-score (partner→SRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.410	+2.000	.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.392	.004	<.001	3	2
UCEC	eIF4E →	+0.184	+2.000	.013	.003	3	2
UCEC	GAPDH →	+0.412	+1.807	.029	.025	3	2
UCEC	PDCD4 →	-0.664	-2.392	<.001	<.001	3	2
UCEC	Rad50 →	-0.189	-2.000	.027	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

SRL survival (RNA) · tumor vs normal (RNA) · all SRL data types