Across TCGA cell cohorts, SRL mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRL-associated genes across cancer lineages are OR56B1, OR6C70, and OR56A5. Each is linked with SRL in more than 1 cancer types. Because this analysis shows association rather than direction, both SRL-to-partner and partner-to-SRL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRL→partner) and Y-score (partner→SRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR56B1 →	+0.048	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.486	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52E6 →	+0.206	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP22-2 →	+0.256	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

SRL survival (RNA) · tumor vs normal (RNA) · all SRL data types