Across TCGA cell cohorts, SRL mutation is significantly associated with the mutation status of many other genes, with 2,496 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRL-associated genes across cancer lineages are PPARD, FRS3, and ITGA7. Each is linked with SRL in more than 3 cancer types. Because this analysis shows association rather than direction, both SRL-to-partner and partner-to-SRL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRL→partner) and Y-score (partner→SRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPARD →	+4.239	+5.053	.007	.007	1	4
SKIN	FRS3 →	+4.239	+5.053	.007	.007	1	4
LUNG_NSCLC_LUAD	ITGA7 →	+4.772	+5.339	.004	.004	1	4
LUNG_NSCLC_LUAD	SLC27A4 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	PA2G4 →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	KIFAP3 →	+4.772	+5.339	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,496 associations by consensus.

Exploration

SRL survival (RNA) · tumor vs normal (RNA) · all SRL data types