SRI

Across TCGA patient cohorts, SRI protein abundance is significantly associated with the RNA expression of many other genes, with 13,836 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SRI-associated genes across cancer lineages are SRI-AS1, TP53TG1, and ZNF862. Each is linked with SRI in more than 6 cancer types. Because this analysis shows association rather than direction, both SRI-to-partner and partner-to-SRI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRI versus SRI-AS1 in HNSC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRI→partner) and Y-score (partner→SRI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRI-AS1 →	+0.623	+0.220	<.001	.001	3	7
HNSC	TP53TG1 →	+0.553	+0.370	<.001	.002	3	6
LUAD	ZNF862 →	+0.770	+0.548	<.001	<.001	3	5
HNSC	BBS9 →	+0.506	+0.288	.001	.002	3	5
OV	BHLHE41 →	+1.142	+0.338	.006	.002	3	5
LUAD	TMEM243 →	+0.869	+0.546	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,836 associations by consensus.

SRI vs SRI-AS1 — HNSC

Explore this scatter interactively →