SRI

Across TCGA patient cohorts, SRI mutation is significantly associated with the RNA expression of many other genes, with 1,584 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRI-associated genes across cancer lineages are H3Y2, DEFA9P, and MIR6833. Each is linked with SRI in more than 1 cancer types. Because this analysis shows association rather than direction, both SRI-to-partner and partner-to-SRI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3Y2 grouped by SRI-low versus SRI-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRI→partner) and Y-score (partner→SRI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	H3Y2 →	+1.298	+5.201	<.001	.007	3	2
CESC	DEFA9P →	+2.577	+5.969	<.001	.002	3	2
BLCA	MIR6833 →	+0.751	+4.429	<.001	.006	3	2
UCEC	LINC01072 →	+0.100	+2.073	.003	.005	3	2
UCEC	RN7SL508P →	+0.153	+2.140	.006	.001	3	2
SKCM	RNU6-275P →	+0.257	+4.302	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,584 associations by consensus.

H3Y2 by SRI expression — CESC

Explore this box plot interactively →