SRI

Across TCGA patient cohorts, SRI mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRI-associated genes across cancer lineages are MEK1, 14-3-3_beta, and EGFR. Each is linked with SRI in more than 1 cancer types. Because this analysis shows association rather than direction, both SRI-to-partner and partner-to-SRI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SRI-low versus SRI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRI→partner) and Y-score (partner→SRI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.424	+2.807	.006	.003	3	2
UCEC	14-3-3_beta →	-0.141	-3.432	<.001	.005	3	1
UCEC	EGFR →	-0.169	-1.700	.012	.044	3	1
UCEC	eIF4E →	+0.211	+2.906	.018	.001	3	1
UCEC	ACC_pS79 →	+0.293	+1.700	.046	.044	3	1
UCEC	Gab2 →	+0.337	+3.169	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by SRI expression — UCEC

Explore this box plot interactively →