SRGN

Across TCGA patient cohorts, SRGN mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. CESC shows the largest number of these associations.

The most reproducible SRGN-associated genes across cancer lineages are RNU6-1301P, RNU6-441P, and RNU6-73P. Each is linked with SRGN in more than 1 cancer types. Because this analysis shows association rather than direction, both SRGN-to-partner and partner-to-SRGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1301P grouped by SRGN-low versus SRGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGN→partner) and Y-score (partner→SRGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1301P →	+0.968	+4.078	<.001	.005	3	1
UCEC	RNU6-441P →	+0.404	+5.885	<.001	.001	3	1
UCEC	RNU6-73P →	+0.370	+4.641	<.001	.006	3	1
UCEC	MIR601 →	+0.902	+4.354	<.001	.002	3	1
UCEC	RNU6ATAC26P →	+0.538	+4.184	<.001	.003	3	1
UCEC	RPS3AP33 →	+0.118	+4.109	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RNU6-1301P by SRGN expression — UCEC

Explore this box plot interactively →