SRGN

Across TCGA cell cohorts, SRGN RNA expression is significantly associated with the go_rna of many other GO terms, with 5,734 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SRGN-associated GO terms across cancer lineages are Substrate adhesion-dependent cell spreading, Peptidyl-lysine oxidation, and Establishment of epithelial cell apical/basal polarity. Each is linked with SRGN in more than 13 cancer types. Because this analysis shows association rather than direction, both SRGN-to-partner and partner-to-SRGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Substrate adhesion-dependent cell spreading grouped by SRGN-low versus SRGN-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGN→partner) and Y-score (partner→SRGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Substrate adhesion-dependent cell spreading →	+0.163	+4.262	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.112	+4.027	.006	.002	2	12
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	+0.241	+3.337	.001	.007	3	11
BREAST	Regulation of plasminogen activation →	+0.234	+2.866	<.001	<.001	3	11
SOFT_TISSUE	Maintenance of protein location in cell →	+0.154	+4.527	<.001	<.001	3	11
SOFT_TISSUE	Maintenance of protein location →	+0.159	+4.835	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,734 associations by consensus.

Substrate adhesion-dependent cell spreading by SRGN expression — SOFT_TISSUE

Explore this box plot interactively →