Across TCGA cell cohorts, SRGAP3 mutation is significantly associated with the RNA expression of many other genes, with 1,734 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRGAP3-associated genes across cancer lineages are F11, OR10A5, and PPP3R2. Each is linked with SRGAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRGAP3-to-partner and partner-to-SRGAP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGAP3→partner) and Y-score (partner→SRGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	F11 →	+0.028	+2.145	.001	.001	3	3
BLOOD_Lymphoma	OR10A5 →	+0.029	+3.392	<.001	.002	3	2
SKIN	PPP3R2 →	+0.011	+2.743	<.001	.005	3	2
LARGE_INTESTINE	ADRA2B →	+0.217	+2.158	.007	.004	3	2
LARGE_INTESTINE	SRMS →	+0.945	+2.491	<.001	.003	3	2
LARGE_INTESTINE	PRDM7 →	+0.149	+3.124	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,734 associations by consensus.

Exploration

SRGAP3 survival (RNA) · tumor vs normal (RNA) · all SRGAP3 data types