Across TCGA cell cohorts, SRGAP3 mutation is significantly associated with the mutation status of many other genes, with 5,706 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRGAP3-associated genes across cancer lineages are ADCY5, NLRP8, and RUNX1T1. Each is linked with SRGAP3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SRGAP3-to-partner and partner-to-SRGAP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGAP3→partner) and Y-score (partner→SRGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADCY5 →	+4.187	+5.000	.008	.008	1	7
LUNG_NSCLC_LUSC	NLRP8 →	+4.228	+4.228	.004	.004	1	5
LUNG_NSCLC_LUSC	RUNX1T1 →	+4.228	+4.228	.004	.004	1	5
OVARY	AUTS2 →	+3.345	+3.345	.007	.007	1	5
SKIN	GALNT17 →	+2.247	+2.402	.002	.002	1	5
LARGE_INTESTINE	COL6A6 →	+2.044	+2.132	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,706 associations by consensus.

Exploration

SRGAP3 survival (RNA) · tumor vs normal (RNA) · all SRGAP3 data types