SRGAP2C

Across TCGA pan-cancer cohorts, SRGAP2C RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SRGAP2C data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SRGAP2C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SRGAP2C expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRP, ACC, and UVM are the cancer types where SRGAP2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.153	0.862	<.001	83	view →
ACC	DFS	Median	All	0.182	0.693	<.001	73	view →
UVM	DFS	Tertile	II,III,IV	0.271	0.710	.001	67	view →
BLCA	OS	Tertile	II,III,IV	0.663	0.786	.002	60	view →
LIHC	OS	Median	All	0.416	0.601	<.001	55	view →
KICH	DFS	Tertile	III,IV	0.273	1.000	.003	53	view →
LGG	DFS	Median	All	0.677	0.796	<.001	48	view →
UCEC	DFS	Median	All	0.776	0.892	<.001	40	view →
HNSC	DFS	Tertile	III,IV	0.436	0.242	.010	25	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	19	view →
PAAD	OS	Quartile	All	0.429	0.695	.017	19	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SRGAP2C–KIRP (OS)

Open the KIRP breakdown →