Across TCGA patient cohorts, SRGAP2B mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRGAP2B-associated genes across cancer lineages are AQP7P3, LCE1E, and IGFL3. Each is linked with SRGAP2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SRGAP2B-to-partner and partner-to-SRGAP2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGAP2B→partner) and Y-score (partner→SRGAP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P3 →	+0.060	+3.997	<.001	.009	3	1
UCEC	LCE1E →	+0.098	+2.838	<.001	.009	3	1
UCEC	IGFL3 →	+0.674	+3.078	<.001	.005	3	1
UCEC	RNU1-15P →	+0.363	+5.151	<.001	.001	3	1
UCEC	RNU6-152P →	+0.538	+3.884	<.001	.002	3	1
UCEC	RNU6-39P →	+0.637	+3.077	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

SRGAP2B survival (RNA) · tumor vs normal (RNA) · all SRGAP2B data types