SRGAP2

Across TCGA cell cohorts, SRGAP2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SRGAP2-associated genes across cancer lineages are NANOGNB, CCDC179, and GHRHR. Each is linked with SRGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRGAP2-to-partner and partner-to-SRGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NANOGNB grouped by SRGAP2-low versus SRGAP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGAP2→partner) and Y-score (partner→SRGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NANOGNB →	+0.111	+5.472	<.001	<.001	3	2
BLOOD_Myeloma	CCDC179 →	+0.040	+4.285	<.001	.003	3	1
URINARY_TRACT	GHRHR →	+0.052	+4.087	<.001	.009	3	1
URINARY_TRACT	CCL25 →	+0.084	+5.044	<.001	<.001	3	1
URINARY_TRACT	CA6 →	+0.086	+4.217	<.001	.005	3	1
URINARY_TRACT	RNASE3 →	+0.032	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

NANOGNB by SRGAP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →