Across TCGA pan-cancer cohorts, SRGAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRGAP1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SRGAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRGAP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SRGAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.583	1.000	<.001	105	view →
HNSC	DFS	Median	All	0.428	0.911	.012	20	view →
PDAC	OS	Quartile	II,III,IV	0.274	0.668	.001	13	view →
LUAD	OS	Median	All	0.593	0.843	.011	3	view →
UCEC	OS	Tertile	All	1.000	0.920	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SRGAP1 tumor-vs-normal RNA expression · all SRGAP1 data types