Across TCGA patient cohorts, SRGAP1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRGAP1-associated genes across cancer lineages are mTOR_pS2448, Cyclin-B1, and STAT3_pY705. Each is linked with SRGAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SRGAP1-to-partner and partner-to-SRGAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRGAP1→partner) and Y-score (partner→SRGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.097	-1.745	.048	.013	3	4
UCEC	Cyclin-B1 →	+0.504	+1.938	.006	.001	3	3
COAD	STAT3_pY705 →	-0.252	-2.691	.017	.006	3	3
UCEC	EGFR_pY1068 →	-0.199	-2.169	.015	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.143	-1.678	.009	.019	3	2
UCEC	MEK1 →	+0.268	+1.765	.026	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

SRGAP1 survival (RNA) · tumor vs normal (RNA) · all SRGAP1 data types