SRFBP1

Across TCGA pan-cancer cohorts, SRFBP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SRFBP1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SRFBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRFBP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SRFBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.616	0.916	<.001	77	view →
HNSC	DFS	Quartile	III,IV	0.442	0.795	.006	28	view →
PDAC	OS	Median	II,III,IV	0.279	0.498	.017	15	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	13	view →
UCEC	OS	Median	II,III,IV	1.000	0.659	.021	6	view →
GBM	OS	Median	All	0.466	0.285	.006	6	view →
LSCC	OS	Tertile	All	0.764	0.899	.022	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SRFBP1–CCRCC (DFS)

Open the CCRCC breakdown →