SRFBP1

Across TCGA patient cohorts, SRFBP1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRFBP1-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Notch1. Each is linked with SRFBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRFBP1-to-partner and partner-to-SRFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SRFBP1-low versus SRFBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRFBP1→partner) and Y-score (partner→SRFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.261	-3.169	.021	.019	3	1
UCEC	MEK1 →	+0.448	+2.459	.006	.019	3	1
UCEC	Notch1 →	+0.248	+2.000	<.001	.032	3	1
UCEC	Annexin-1 →	+0.577	+2.999	.015	.035	3	1
UCEC	4E-BP1_pS65 →	+0.183	+3.169	.037	.019	3	1
UCEC	Caspase-8 →	-0.244	-3.459	.031	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by SRFBP1 expression — UCEC

Explore this box plot interactively →