SRF

Across TCGA pan-cancer cohorts, SRF mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SRF data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRF expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where SRF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.720	0.978	<.001	94	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	18	view →
CCRCC	DFS	Quartile	II,III,IV	0.767	0.435	.020	14	view →
LSCC	DFS	Tertile	II,III,IV	0.915	0.214	.006	10	view →
PDAC	DFS	Tertile	IV	0.245	0.934	.038	6	view →
GBM	OS	Quartile	All	0.640	0.385	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SRF–HNSC (DFS)

Open the HNSC breakdown →