SRF

Across TCGA pan-cancer cohorts, SRF mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SRF’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SRF mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SRF is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUAD and CCRCC are the cancer types where SRF tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRF mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.484	<.001	9	view →
CCRCC	Male	All	+0.693	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SRF–LUAD

Open the LUAD breakdown →