SRF

Across TCGA patient cohorts, SRF mutation is significantly associated with the RNA expression of many other genes, with 2,990 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRF-associated genes across cancer lineages are RNU6-349P, RN7SKP104, and RNU6-99P. Each is linked with SRF in more than 1 cancer types. Because this analysis shows association rather than direction, both SRF-to-partner and partner-to-SRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-349P grouped by SRF-low versus SRF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRF→partner) and Y-score (partner→SRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-349P →	+0.283	+7.816	<.001	.008	3	1
SKCM	RN7SKP104 →	+0.099	+7.816	<.001	.008	3	1
SKCM	RNU6-99P →	+0.463	+7.816	<.001	.008	3	1
CESC	NEUROD6 →	+0.025	+5.812	<.001	.003	3	1
CESC	DEFB109B →	+0.200	+5.969	<.001	.002	3	1
CESC	RNA5SP198 →	+0.374	+6.144	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,990 associations by consensus.

RNU6-349P by SRF expression — SKCM

Explore this box plot interactively →