SRF

Across TCGA patient cohorts, SRF mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRF-associated genes across cancer lineages are p62 Lck ligand, Rad50, and Tuberin. Each is linked with SRF in more than 1 cancer types. Because this analysis shows association rather than direction, both SRF-to-partner and partner-to-SRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SRF-low versus SRF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRF→partner) and Y-score (partner→SRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.352	+3.331	.007	.005	3	1
UCEC	Rad50 →	-0.209	-2.986	.032	.035	3	1
UCEC	Tuberin →	+0.305	+3.169	.004	.018	3	1
UCEC	ATM →	-0.361	-1.906	.048	.016	3	1
UCEC	Beclin →	-0.082	-2.321	.030	.033	3	1
UCEC	beta-Catenin →	+0.402	+2.321	.049	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p62 Lck ligand by SRF expression — UCEC

Explore this box plot interactively →