SRF

Across TCGA cell cohorts, SRF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,697 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRF-associated GO terms across cancer lineages are Trophectodermal cell differentiation, Negative regulation of amyloid-beta clearance, and Nucleic acid transport. Each is linked with SRF in more than 19 cancer types. Because this analysis shows association rather than direction, both SRF-to-partner and partner-to-SRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trophectodermal cell differentiation grouped by SRF-low versus SRF-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRF→partner) and Y-score (partner→SRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Trophectodermal cell differentiation →	+0.188	+0.830	<.001	<.001	3	20
BREAST	Negative regulation of amyloid-beta clearance →	+0.170	+1.004	<.001	<.001	3	14
BLOOD_Lymphoma	Nucleic acid transport →	+0.103	+0.934	<.001	<.001	3	13
BLOOD_Lymphoma	RNA transport →	+0.103	+0.934	<.001	<.001	3	13
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.087	+0.688	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of cell cycle G1/S phase transition →	+0.054	+0.751	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,697 associations by consensus.

Trophectodermal cell differentiation by SRF expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →