SRF

Across TCGA cell cohorts, SRF mutation is significantly associated with the mutation status of many other genes, with 2,057 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRF-associated genes across cancer lineages are NFRKB, PDE3B, and ILF3. Each is linked with SRF in more than 3 cancer types. Because this analysis shows association rather than direction, both SRF-to-partner and partner-to-SRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFRKB grouped by SRF-low versus SRF-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRF→partner) and Y-score (partner→SRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NFRKB →	+6.044	+6.044	.001	.001	1	4
BLOOD_Lymphoma	PDE3B →	+4.169	+5.316	<.001	<.001	1	4
CNS	ILF3 →	+4.459	+5.277	.005	.005	1	3
CNS	BTBD11 →	+4.459	+5.277	.005	.005	1	3
CNS	RALGAPB →	+6.044	+6.044	.001	.001	1	3
CNS	KAT5 →	+4.459	+5.277	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,057 associations by consensus.

NFRKB by SRF expression — CNS

Explore this box plot interactively →