SREK1IP1

Across TCGA patient cohorts, SREK1IP1 mutation is significantly associated with the RNA expression of many other genes, with 2,253 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREK1IP1-associated genes across cancer lineages are RNU6-1085P, RNU4-60P, and VN1R91P. Each is linked with SREK1IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREK1IP1-to-partner and partner-to-SREK1IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1085P grouped by SREK1IP1-low versus SREK1IP1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREK1IP1→partner) and Y-score (partner→SREK1IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1085P →	+0.400	+5.435	<.001	.005	3	2
SKCM	RNU4-60P →	+0.430	+5.224	<.001	.007	3	2
UCEC	VN1R91P →	+0.211	+2.814	<.001	.003	3	2
READ	ATP5F1AP10 →	+0.072	+5.653	<.001	.003	3	1
HNSC	RNU6-517P →	+0.409	+5.124	<.001	.008	3	1
HNSC	MIR191 →	+0.371	+5.435	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,253 associations by consensus.

RNU6-1085P by SREK1IP1 expression — HNSC

Explore this box plot interactively →