SREK1IP1

Across TCGA patient cohorts, SREK1IP1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREK1IP1-associated genes across cancer lineages are A-Raf_pS299, ERK2, and JNK_pT183_Y185. Each is linked with SREK1IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREK1IP1-to-partner and partner-to-SREK1IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SREK1IP1-low versus SREK1IP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREK1IP1→partner) and Y-score (partner→SREK1IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.161	-2.999	.002	.035	3	1
UCEC	ERK2 →	+0.257	+2.115	.002	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-3.321	.006	.010	3	1
UCEC	Ku80 →	+0.339	+2.820	<.001	.001	3	1
UCEC	Annexin-1 →	+0.630	+3.169	.006	.018	3	1
UCEC	Shc_pY317 →	-0.165	-2.321	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

A-Raf_pS299 by SREK1IP1 expression — UCEC

Explore this box plot interactively →