SREK1

Across TCGA patient cohorts, SREK1 mutation is significantly associated with the RNA expression of many other genes, with 4,594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREK1-associated genes across cancer lineages are NCAPD3, BAG3, and ATP5F1A. Each is linked with SREK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREK1-to-partner and partner-to-SREK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPD3 grouped by SREK1-low versus SREK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREK1→partner) and Y-score (partner→SREK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPD3 →	+0.753	+3.258	<.001	<.001	3	2
UCEC	BAG3 →	+0.648	+4.151	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.442	+2.010	<.001	<.001	3	2
UCEC	PELO →	+0.575	+2.010	<.001	<.001	3	2
UCEC	BUB3 →	+0.549	+3.162	<.001	<.001	3	2
UCEC	TRMT44 →	+0.328	+3.056	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,594 associations by consensus.

NCAPD3 by SREK1 expression — UCEC

Explore this box plot interactively →