SREK1

Across TCGA patient cohorts, SREK1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREK1-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and GAPDH. Each is linked with SREK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SREK1-to-partner and partner-to-SREK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SREK1-low versus SREK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREK1→partner) and Y-score (partner→SREK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.616	+2.019	.002	.005	3	3
UCEC	FoxM1 →	+0.190	+1.440	.034	.024	3	2
UCEC	GAPDH →	+0.518	+2.584	.005	.010	3	2
UCEC	MIG-6 →	+0.069	+1.453	.043	.015	3	2
UCEC	PDCD4 →	-0.615	-3.990	<.001	<.001	3	2
UCEC	PKC-b-II_pS660 →	-0.210	-1.906	.028	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Caspase-7-cleavedD198 by SREK1 expression — UCEC

Explore this box plot interactively →