SREK1

Across TCGA cell cohorts, SREK1 mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SREK1-associated genes across cancer lineages are UNC0642, LMB_AB3, and MK-1775. Each is linked with SREK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREK1-to-partner and partner-to-SREK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC0642 grouped by SREK1-low versus SREK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREK1→partner) and Y-score (partner→SREK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC0642 →	+0.180	+2.881	.045	.019	3	1
LARGE_INTESTINE	LMB_AB3 →	+0.343	+2.684	.034	.035	3	1
LARGE_INTESTINE	MK-1775 →	+0.301	+2.678	.042	.037	2	1
LARGE_INTESTINE	Dinaciclib →	+0.502	+2.672	.031	.039	2	1
LARGE_INTESTINE	CP466722 →	+0.367	+3.067	.041	.009	2	1
LARGE_INTESTINE	PFI3 →	+0.210	+2.754	.047	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

UNC0642 by SREK1 expression — LARGE_INTESTINE

Explore this box plot interactively →