Across TCGA patient cohorts, SREBF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,395 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SREBF2-associated proteins across cancer lineages are HMGCS1, IDI1, and MSMO1. Each is linked with SREBF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SREBF2-to-partner and partner-to-SREBF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF2→partner) and Y-score (partner→SREBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HMGCS1 →	+0.878	+0.886	<.001	<.001	3	7
GBM	IDI1 →	+0.541	+0.759	<.001	<.001	3	6
LSCC	MSMO1 →	+0.512	+0.576	<.001	<.001	3	6
OV	ACAT2 →	+0.493	+1.016	<.001	<.001	3	6
LSCC	ST13 →	+0.331	+0.661	<.001	<.001	3	5
HNSC	FDFT1 →	+0.650	+0.880	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,395 associations by consensus.

Exploration

SREBF2 survival (RNA) · tumor vs normal (RNA) · all SREBF2 data types