Across TCGA patient cohorts, SREBF2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,068 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SREBF2-associated genes across cancer lineages are HMGB1, CORO2A, and ALDH3A1. Each is linked with SREBF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREBF2-to-partner and partner-to-SREBF2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF2→partner) and Y-score (partner→SREBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMGB1 →	+0.534	+0.309	<.001	<.001	3	2
HNSC	CORO2A →	+1.321	+0.537	<.001	.001	3	2
HNSC	ALDH3A1 →	+3.757	+0.492	.001	.003	3	2
HNSC	ZBTB7C →	+1.815	+0.623	.003	<.001	3	2
HNSC	RNU6-1161P →	+1.784	+0.612	.004	<.001	3	2
HNSC	RNU6-904P →	+0.758	+0.507	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,068 associations by consensus.

Exploration

SREBF2 survival (RNA) · tumor vs normal (RNA) · all SREBF2 data types