Across TCGA patient cohorts, SREBF2 mutation is significantly associated with the RNA expression of many other genes, with 2,683 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREBF2-associated genes across cancer lineages are SKA1, CDCA2, and WDR81. Each is linked with SREBF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SREBF2-to-partner and partner-to-SREBF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF2→partner) and Y-score (partner→SREBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKA1 →	+0.826	+3.472	<.001	.002	3	3
UCEC	CDCA2 →	+0.556	+1.584	<.001	<.001	3	3
SKCM	WDR81 →	+0.616	+3.497	.001	.002	3	3
SKCM	FEN1 →	+0.477	+2.328	.009	.003	3	3
UCEC	CDKN3 →	+0.544	+1.595	.001	<.001	3	3
SKCM	PARP2 →	+0.480	+2.341	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,683 associations by consensus.

Exploration

SREBF2 survival (RNA) · tumor vs normal (RNA) · all SREBF2 data types